Organized at Benton Barracks, Mo., as the 13th Missouri Infantry and mustered in November 5, 1861. Ordered to Cairo, Ill., January 26, 1862. Attached to 2nd Brigade, 2nd Division, District of West Tennessee and Army of the Tennessee, to July, 1862. Designation of Regiment changed to 22nd Ohio Infantry July 7, 1862. 2nd Brigade, 2nd Division, District of Corinth, Miss., to September, 1862. 1st Brigade, 2nd Division, District of Corinth, Miss., to October, 1862. 2nd Brigade, 2nd Division, District of Corinth, Miss., to November, 1862. 2nd Brigade, District of Corinth, Miss., 13th Army Corps (Old), Dept. of the Tennessee, to December, 1862. 2nd Brigade, District of Corinth, 17th Army Corps. to January, 1863. 4th Brigade, District of Jackson, 16th Army Corps, Army of the Tennessee, to March, 1863. 2nd Brigade, 3rd Division, 16th Army Corps, to May, 1863. Kimball's Provisional Division, 16th Army Corps, to July, 1863. 2nd Brigade, Kimball's Division, District of Eastern Arkansas, to August, 1863. 2nd Brigade, 2nd Division, Arkansas Expedition, to January, 1864. 2nd Brigade, 2nd Division, 7th Army Corps, Dept. of Arkansas, to March, 1864. 3rd Brigade, 3rd Division, 7th Army Corps, Dept. of Arkansas, to May, 1864. 2nd Brigade, 2nd Division, 7th Army Corps, to February, 1865. 1st Brigade, 3rd Division, 7th Army Corps, to August, 1865.

SERVICE:
Reconnoissance from Smithland, Ky., toward Fort Henry, Tenn., January 31-February 2. Operations against Fort Henry, Tenn., February 2-6. Capture of Fort Henry February 6. Investment and capture of Fort Donelson, Tenn., February 12-16. Expedition to Clarksville and Nashville, Tenn., February 22- March 5. Moved to Pittsburg Landing, Tenn., March 14-17. Battle of Shiloh April 6-7. Advance on and siege of Corinth, Miss., April 29-May 30. Pursuit to Booneville June 1-6. Duty at Corinth, Miss., till October. Expedition to Iuka, Miss., September 17-19. Battle of Corinth October 3-4. Pursuit to Ripley October 5-12. Box Ford, Hatchie River October 7 (3 Cos.). Near Ruckersville October 7 (Detachment). Near Ripley October 7 (Detachment). Garrison at Trenton and duty along line of the Mobile & Ohio Railroad till March, 1863. Near Yorkville January 28, 1863. Dyersburg January 30. Moved to Jackson, Tenn., March 11, thence to Corinth, Miss., April 29, and return to Jackson, Tenn., May 3. Ordered to Memphis, Tenn., May 20, thence to Vicksburg, Miss., June 1. Siege of Vicksburg June 3-July 4. Surrender of Vicksburg July 4. Ordered to Helena, Ark., July 16. Steele's Expedition to Little Rock, Ark., August 13-September 10. Bayou Fourche and capture of Little Rock September 10. Duty at Little Rock till October 28. Ordered to Brownsville October 28, and duty there till October 24, 1864. Near Searcy May 18, 1864. Near Brownsville July 13. Near Searcy August 13. Ordered to Camp Dennison, Ohio, October 24. Mustered out November 18, 1864. Veterans and Recruits consolidated to two Companies and mustered out August 28, 1865.
Regiment lost during service 2 Officers and 36 Enlisted men killed and mortally wounded and 2 Officers and 167 Enlisted men by disease. Total 207.