2nd Infantry Regiment completed its organization at Corinth, Mississippi, in April, 1861, with men from Tishomingo, Tippah, Itawamba, and Pontotoc counties. Ordered to Harper's Ferry, Virginia, it was there mustered into Confederate service with 784 officers and men. During the war it was assigned to General Whiting's, Law's, and J.R. Davis' Brigade, Army of Northern Virginia. After fighting at First Manassas, the regiment served with the army from Seven Pines to Cold Harbor, except when it was detached to Suffolk with Longstreet. It saw action in the Petersburg siege south of the James River and in numerous conflicts around Appomattox. The 2nd reported 25 killed and 82 wounded at First Manassas and totalled 477 men in April, 1862. It sustained 111 casualties during the Seven Days' Battles, 97 at Second Manassas, and 154 in the Maryland Campaign. Of the 492 engaged at Gettysburg, more than forty-five percent were disabled. Only 1 officer and 19 men surrendered. The field officers were Colonels William C. Falkner and John M. Stone; Lieutenant Colonels John A. Blair, Bartley B. Boone, and D.W. Humphreys; and Major John H. Buchanan.