45th Infantry Regiment was organized at Camp Mangum, near Raleigh, North Carolina, in April, 1862, with men from Rockingham, Caswell, Guilford, and Forsyth counties. It served under the command of Generals Daniel and Grimes. After fighting at Malvern Cliff in Virginia, it returned to North Caroina and was stationed in the Kinston-New Bern area. During the spring of 1863 the unit moved north and took an active part in the campaigns of the Army of Northern Virginia from Gettysburg to Cold Harbor. It continued the fight with Early in the Shenandoah Valley and ended the war at Appomattox. It reported 2 killed and 14 wounded at Malvern Cliff, lost about forty percent of the 570 engaged at Gettysburg, and sustained 2 casualties at Bristoe and 6 at Mine Run. The unit surrendered with 7 officers and 88 men. The field officers were Colonels Samuel H. Boyd, Junius Daniel, John H. Morehead, and John R. Winston; Lieutenant Colonels Andrew J. Boyd and James S. Dalton; and Majors Samuel C. Rankin, Charles E. Shober, and T. McGehee Smith.