16th Infantry Regiment [also called Sallie Twiggs Regiment] was organized during the early summer of 1861. Its companies were raised in the counties of Madison, Elbert, Gwinnett, Habersham, Jackson, and Hart. Sent to Virginia the regiment was assigned to General H. Cobb's, T.R.R. Cobb's, Wofford's, and DuBose's Brigade. It fought with the Army of Northern Virginia from the Seven Days' Battles to Gettysburg, then moved with Longstreet but was not engaged in the fight at Chickamauga. After serving at Knoxville, it returned to Virginia and participated in the conflicts at The Wilderness, Spotsylvania, and Cold Harbor. Later the unit was part of Early's operations in the Shenandoah Valley and the Appomattox Campaign. The regiment had a force of 488 effectives in April, 1862, lost 11 killed and 50 wounded at Malvern Hill, and of the 368 engaged at South Mountain, fifty-two percent were disabled. It sustained 70 casualties at Fredericksburg, 133 at Chancellorsville, and twenty-six percent of the 303 at Gettysburg. The 16th lost many at Sayler's Creek and surrendered 2 officers and 51 men. Its commanders were Colonels Goode Bryan, Howell Cobb, James S. Gholston, and Henry P. Thomas; Lieutenant Colonel B. Edward Stiles; and Major John H. Skelton.