16th Infantry Regiment was organized in June, 1861, at Camp Harris, Tennessee, with 952 officers and men. Its companies were drawn from the counties of DeKalb, Coffee, Warren, Putnam, and White. Sent to Virginia, the unit was active in Lee's Cheat Mountain Campaign and later moved to South Carolina, Georgia, Alabama, Mississippi, then Kentucky. After fighting at Perryville, it was assigned to M.J. Wright's, Maney's, and Palmer's Brigade, Army of Tennessee. The regiment participated in the campaigns of the army from Murfreesboro to Atlanta, endured Hood's winter operations, and saw action in North Carolina. It reported 199 casualties at Perryville and lost fifty-two percent of the 402 engaged at Murfreesboro. Of the 242 at Chickamauga, twenty-eight percent were disabled and in December, 1863, it totalled 212 men and 157 arms. The unit surrendered on April 26, 1865. Its field officers were Colonels David M. Donnell and John H. Savage; Lieutenant Colonels Daniel T. Brown and Thomas B. Murray; and Majors Patrick H. Coffee, Henry H. Faulkner, Joseph Goodbar, and Ben. Randals.