Organized at Camp Dennison, Ohio, June 28, 1861. Left State for the Kanawha Valley, W. Va., July 6. Attached to Cox's Kanawha Brigade, W. Va., to September, 1861. Benham's Brigade, Dist. of the Kanawha, W. Va., to October, 1861. 1st Brigade, District of the Kanawha, to March, 1862. 1st Brigade, Kanawha Division West Virginia, Dept. of the Mountains, to September, 1862. 1st Brigade, Kanawha Division, 9th Army Corps, Army of the Potomac, to October, 1862. 1st Brigade, Kanawha Division, District of West Virginia, Dept. of the Ohio, to March, 1863. 1st Brigade, 3rd Division, 8th Army Corps, Middle Department, to June, 1863. 2nd Brigade, Scammon's Division, Dept. of West Virginia, to December, 1863. 2nd Brigade, 3rd Division, Army of West Virginia, to April, 1864. 2nd Brigade, 2nd Infantry, Division West Virginia, to July, 1864.

SERVICE:
Action at Scary Creek, W. Va., July 17, 1861. Battle of Carnifex Ferry September 10. Operations in the Kanawha Valley, W. Va., and New River Region September to November. Gauley River September 12. Wilderness Ferry September 14. Hough's Ferry September 16. Advance to Sewell Mountain September 24. Sewell Mountain September 25. At Hawk's Nest October 10 to November 1. Movement on Cotton Mountain and pursuit of Floyd November 1-18. Laurel Creek November 12 (Co. "H"). Duty at Charleston till April, 1862. Advance on Princeton April 22-May 1. Narrows of New River May 4. Operations on Flat Top Mountain May 20 to August 14. Scout in Wayne County July 24-26 (Detachment). Moved to Washington August 14-24. Pope's Campaign in Northern Virginia August 24-September 2. Action at Bull Run Bridge August 27. Maryland Campaign September 6-22. Battle of South Mountain, Md., September 14. Battle of Antietam September 16-17. March to Clear Springs October 8, thence to Hancock and to the Kanawha Valley, W. Va., October 14-November 17. Moved to Fayette Court House December 4, and duty there till May, 1864. Action at Blake's Farm May 9, 1863. Repulse of McCausland's attack on Fayetteville May 17-20, 1863. Fayette Court House May 19. Pursuit of Morgan's forces and patrol on the Ohio River July 17-26. Expedition from Charlestown to Lewisburg November 3-13. Action at Meadow Bluff December 4, 1863. Scammon's demonstration from the Kanawha Valley December 8-25, 1863. Action at Big Sewell Mountain and Meadow Bluff Deber 11. Lewisburg and Greenbrier River December 12. Near Meadow Bluff December 14. Crook's Raid on Virginia & Tennessee Railroad May 2-19. Princeton May 6 (Cos. "B," "D"). Battle of Cloyd's Mountain May 9. New River Bridge May 10. Hunter's Raid to Lynchburg May 26-July 1. Diamond Hill June 17. Lynchburg June 17-18. Retreat to Charleston June 19-July 1. Ordered to Columbus, Ohio, July 2. Veterans and Recruits transferred to 23rd Ohio Infantry. Mustered out July 11, 1864, expiration of term.
Regiment lost during service 3 Officers and 93 Enlisted men killed and mortally wounded and 2 Officers and 77 Enlisted men by disease. Total 175.