22nd Infantry Regiment, formerly known as the 1st Kanawha Regiment, was organized and accepted into Confederate service in July, 1861. Its members were from the counties of Jackson, Craig, Nicholas, Alleghany, Wyoming, and Boone. The 22nd saw action at Carnifex Ferry and later lost twenty-one percent of the 550 engaged at Droop Mountain. It was assigned to Echols' and Patton's Brigade, participated in the Shenandoah Valley operations, and disbanded during the spring of 1865. The field officers were Colonels George S. Patton and C.Q. Tompkins; Lieutenant Colonels Andrew R. Barbee, William A. Jackson, and John C. McDonald; and Majors Robert A. Bailey and Isaac N. Smith.