Duty in the Dept. of New Mexico throughout the war, operating against Indians. Battle of Valverde, N.M., February 21, 1862 (Cos. "B," "D," "F," "I"). Evacuation of Albuquerque and Santa Fe March 2-4, 1862 (1 Co.). Action at Apache Canon March 28, 1862 (Cos. "A," "G"). Peralta April 15. Companies "D," "E," "F" and "G" joined Gen. Carlton's Command at Las Cruces August 10, 1862, Companies "A," "B," "I" and "K" at Fort Craig. Pecos River near Fort Sumner January 5, 1864 (Co. "D"). Expedition against Indians in Central Arizona December 26, 1864 - January 1, 1865.

Regiment lost during service 2 Officers and 18 Enlisted men killed and mortally wounded and 2 Officers and 35 Enlisted men by disease. Total 57.