Edward D. Holdridge was born around 1821 in Connecticut. By the mid-1840s, he was living in Colchester, Connecticut. He married Lucy A. Daniels on August 23, 1846, and they had at least three children: Edward, born around 1854; Addie, born around 1857; and Alice, born around 1861. They lived in Glastonbury, Connecticut, and he worked as a harness maker.
He enlisted in the Union army on January 21, 1862, and he mustered in as a private in Company A of the 12th Connecticut Infantry. The regiment took part in the siege of Port Hudson and the Shenandoah Valley campaign. He mustered out on January 20, 1865.
He settled in Windsor, Connecticut, after the war, and he earned a living as a house painter. His wife worked as a dressmaker, and by 1870, the family owned $150 of personal property. They moved to Winchester, Connecticut, in the 1870s. His wife died on September 16, 1883, and he died in Colchester on June 28, 1886.