Anne Frances Burr (maiden name: Hardon) was born on March 26, 1827, in Mansfield, Massachusetts, to Comfort Hardon and Anna Field. Her father was a “cistern builder.” The family moved to Martinsburg, Virginia (present-day West Virginia), around 1841, but Anne eventually returned to Massachusetts. She married Isaac Tucker Burr on August 31, 1852, and they had at least seven children: Ann, born around 1854; Cora, born around 1855; Heman, born around 1856; Isaac, born around 1858; Winthrop, born around 1862; Bertha, born around 1863; and Allston, born around 1867.
They lived in Newton, Massachusetts, and her husband worked as a merchant. By 1870, they owned $130,000 of real estate and $100,000 of personal property. In the 1870s, he became president of the Boston branch of the National Bank of North America. Her husband died in 1904. Anne remained in their home in Newton, and by 1910, she employed three maids, a cook, a gardener, and a coachman. She died in Newton on December 2, 1917.