22nd Infantry Regiment completed its organization at Montogmery, Alabama, in November, 1861, then moved to Mobile. Its companies were raised in the counties of Walker, Clarke, Cherokee, Mobile, Pike, Choctaw, Montgomery, Calhoun, and Randolph. The unit suffered severe losses at Shiloh under General Gladden, then saw action in Bragg's Kentucky Campaign under General Gardner. Later the 22nd was attached to Deas', G.D. Johnston's, and Brantley's Brigade, Army of Tennessee. It fought in many conflicts from Murfreesboro to Atlanta, was part of General Hood's winter operations in Tennessee, and ended the war in North Carolina. After the Battle of Shiloh, the regiment reported only 123 men fit for duty. It sustained 94 casualties at Murfreesboro, and lost fifty-three percent of the 371 engaged at Chickamauga. In December, 1863, it totalled 272 men and 171 arms. It reported 5 killed and 35 wounded in the fight at Ezra Church; many were also disabled at Franklin and Nashville. The regiment was included in the surrender on April 26, 1865. Its field officers were Colonels Zach C. Deas, B.R. Hart, John C. Marrast, and Harry T. Houlmin; Lieutenant Colonels E. Herbert Armistead, Napoleon B. Rouse, and John Weedon; and Majors Robert B. Armistead, Robert Donnell, and T.M. Prince.
