Edward Manigault was born on March 8, 1817, in Charleston, South Carolina, to Joseph Manigault and Charlotte Drayton. He graduated from South Carolina College in 1835. He served in the 12th South Carolina Infantry during the Mexican American War, earning a promotion to major on July 16, 1847. Manigault worked as a civil engineer in Charleston, and by 1860, he owned $12,000 of real estate and $15,000 of personal property. He served as South Carolina’s chief of ordnance during the early months of the Civil War. On October 31, 1861, he became a major in the 6th South Carolina Infantry battalion. In June 1863, army officials transferred him to an artillery battalion, which became known as Manigault’s Battalion. He was severely wounded during the Battle of Grimball’s Causeway on February 20, 1865. Surgeons amputated his leg, but he survived and eventually recovered. He received his parole on May 10, 1865. Manigault settled in Georgetown County, South Carolina, during the Civil War. He died there on October 2, 1874.