William Vaughn Witherspoon was born around 1837 in South Carolina to Charles and Frances Witherspoon. His father was a farmer who owned $17,070 of real estate and $28,000 of personal property by 1860. He grew up and attended school in Sumter, South Carolina, and the family moved to Clarendon, South Carolina, in the 1850s.
He enlisted in the Confederate army on June 19, 1861, and he mustered in as a private in Company C of Hampton’s Legion. He was promoted to corporal on April 26, 1862, then to 2nd lieutenant in the fall of 1862. The regiment took part in the First Battle of Bull Run, the Peninsula campaign, the Seven Days’ Battles, the Second Battle of Bull Run, the Battle of Antietam, the Battle of Gettysburg, the Overland Campaign, and the siege of Petersburg.
Witherspoon returned to Clarendon County after the war. He married Ida Cunningham, and they had at least three children: Herbert, born around 1872; William, born around 1874; and Annie, born around 1877. He died of consumption in Clarendon County on January 11, 1880.