Green B. Huddleston was born around 1841 in Tennessee to John and Lucilla Huddleston. His father was a farmer who owned $4,000 of real estate and $7,000 of personal property by 1860. The family lived in Jackson County, Tennessee, until the 1850s, when they moved to Putnam County, Tennessee.
He enlisted in the Confederate army on August 2, 1862, and he mustered in as a private in Company C of the 13th Tennessee Cavalry. Union forces captured him on December 31, 1862, and imprisoned him at Camp Douglas in Illinois. He died of smallpox on March 13, 1863.