Thomas Fisher was born on January 20, 1802, in Pennsylvania to Samuel and Rebecca Fisher. His mother died when he was around six months old. He began working as a clerk in a store around 1816. He married Rachel Jackson, and they had at least eight children: Fanny, born around 1831; Horatio, born on April 21, 1838; Wilhemina, born around 1839; Thomas, born around 1841; Hetty, born around 1843; John, born around 1846; Catherine, born around 1848; and Isabella, born around 1851. They lived in Huntingdon, Pennsylvania, and Fisher worked as a merchant. He supported the Whig Party.
By 1850, he owned $21,800 of real estate. A decade later, he owned $40,000 of real estate and $10,000 of personal property, and by 1870, his wealth had grown to $57,000 of real estate and $33,000 of personal property. A local writer declared him “one of the worthiest and most venerable citizens of Huntingdon.” He eventually became president of the First National Bank of Huntingdon. His wife died in the 1870s, and he died in Huntingdon on August 2, 1883.