Samuel Scott Walker was born around 1807 in Kentucky. He moved to central Illinois as a young man and then to Jefferson County in the Iowa Territory in the early 1840s. He married Sarah Allen, and they had at least eight children: Ann, born around 1832; Mary, born around 1834; Cyrus, born around 1836; Louisa, born around 1842; James, born around 1844; Jane, born around 1846; Melissa, born around 1847; and Custus, born around 1849. They moved to the Iowa Territory in the 1830s. Walker worked as a farmer, and by 1850, he owned $300 of real estate. He supported the Whig Party, and he was their candidate for sheriff in 1851. After the Whig Party collapsed in the 1850s, he reportedly “never thereafter acted in full accord with either of the other parties.”
The family moved to Pleasant, Iowa, around 1852, and by 1860, he owned $3,000 of real estate and $1,494 of personal property. A decade later, his wealth had grown to $5,000 of real estate and $4,000 of personal property. He moved to Eudora, Kansas, in the 1870s. His wife died on November 26, 1882, and by the early 1890s, he was living in Bartow, Florida. He died there in 1892.