Isaac W. Fry was born on January 17, 1844, in Shippenville, Pennsylvania, to Adam and Esther Fry. His father was a farmer who owned $5,000 of real estate and $400 of personal property by 1860. He grew up and attended school in Venango County, Pennsylvania, and by 1860, he was also working as a farmer.
He enlisted in the Union army in August 1862, and he mustered in as a private in Company F of the 121st Pennsylvania Infantry. The regiment took part in the Battle of Fredericksburg, the Battle of Chancellorsville, the Battle of Gettysburg, the Overland Campaign, and the Appomattox campaign.
He remained committed to the Union war effort. In May 1863, he insisted that “genrel grand is driving [Confederates] out of wicksburg and if genrel grand is succesful in driving them out of wicksburgh it wont be much of a job to take richmond.” He confessed that “I am tired of fighting I have seen about as much fighting as I care about but if the war cant be setelt with out then fight it is.” He added that “I would rether stay in the army five years yet then to let the rebs rule over us.”He mustered out on June 2, 1865.
He settled in Concord, Indiana, after the war, and he earned a living as a farmer. By 1870, he owned $300 of real estate and $690 of personal property. He married Jemima Clay on April 9, 1868, and they had at least seven children: Harry, born around 1869; Frank, born around 1870; Charles, born around 1872; William, born around 1874; Clarence, born around 1876; Hettie, born around 1879; and Grace, born around 1884.
They moved to Colfax, Missouri, around 1871. His wife died on January 5, 1925. His health deteriorated in the 1920s, and he lost his eyesight in 1929. He died of pneumonia in De Kalb County, Missouri, on September 20, 1929.